This is a lengthy thread and I haven't actual read through it, but I will agree completely with Omni's original comment. I use MP extensively (I used to compute POC moves in my head well before they happened...pretty geeky, but that is my approach). I must say, however, that I don't look at TPO's at all. I believe that, for my approach, it is a completely outdated look on the market. 30 min TPO's made sense when Steidlemeyer didn't have access to real time and accurate volume data (mostly floor trading at that time).
I look at volume profiles almost exclusively when it comes to assessing and using the auction as my main market-generated input. I tweet a lot on this subject and have held a couple of chats/webinars on it at various places.
I think the most important thing to take away from here is that MP or VP is NOT a system. It is simply a way of categorizing or organizing the market. It is what you do with that information that dictates which one suits your needs. Again, I find it easier to go with volume than TPO, but that is just a personal preference for the setups I trade.
Cheers,
FT71